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While small-count MBL rarely progresses to CLL, substantial-rely MBL progresses to CLL demanding therapy at a amount of 1% to 2% each year. High-depend MBL is distinguished from Rai 0 CLL determined by if the B-cell rely is previously mentioned or underneath five × 109/L. Although people with both equally high-count MBL and CLL Rai stage 0 are at